Bioequivalence and Bioavailability Forum • power.TOST.sim code

power.TOST.sim code [Outliers]

posted by mittyri – Russia, 2023-10-31 16:40 (561 d 08:06 ago) – Posting: # 23770
Views: 5,085

Dear BEQool!

❝ Distributions (both normal and log-normal) are determined by their mean and variance. As discussed above, in order to get power we need distribution of PE; the mean is of course PE but what about the variance? Is the variance of PE distribution MSE? Or something else?

I think it is better to look into the code


  # simulate point est. via normal distribution

  pes   <- rnorm(n=nsims, mean=diffm, sd=se.fac*sqrt(mse))

  # simulate mse via chi-squared distribution

  mses  <- mse*rchisq(n=nsims, df=df)/df

So the variance is calculated based on MSE, design constant and the number of subjects:

  

power.TOST.sim <- function(<...>) {

  <...>

  d.no  <- .design.no(design)

  <...>

  ades  <- .design.props(d.no)

  <...>

  nc <- sum(1/n)

  <...>

  se.fac <- sqrt(ades$bkni * nc)

  <...>

}

—
Kind regards,
Mittyri

Complete thread:

Outlier in fully replicate BE study Loky do 2021-06-16 00:49 [Outliers]
- Outlier in fully replicate BE study drgunasakaran1 2021-06-16 08:59
  - Widening for clopidogrel BE study Loky do 2021-06-16 15:38
    - Widening for clopidogrel BE study mittyri 2021-06-16 16:04
      - Widening for clopidogrel BE study Loky do 2021-06-16 17:08
        
        Widening for clopidogrel BE study - cherry-picking? mittyri 2021-06-16 17:27
        Widening for clopidogrel BE study drgunasakaran1 2021-06-17 12:01
        Hypotheses Helmut 2021-06-19 12:32
        
        Hypotheses Loky do 2021-07-06 11:51
        
        ABEL ≠ RSABE Helmut 2021-07-06 16:17
        
        ABEL ≠ RSABE BEQool 2023-10-09 14:47
        
        power.TOST.sim and uncertainty mittyri 2023-10-11 12:42
        
        power.TOST.sim and uncertainty BEQool 2023-10-15 11:29
        
        power.TOST.sim and uncertainty mittyri 2023-10-20 21:47
        
        Distribution of PEs Helmut 2023-10-23 10:48
        
        Distribution of PEs BEQool 2023-10-23 19:55
        
        power.TOST.sim codemittyri 2023-10-31 15:40
        
        power.TOST.sim code BEQool 2023-11-02 11:22