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posted by martin  – Austria, 2008-09-19 15:13 (6064 d 20:23 ago) – Posting: # 2377
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dear Yung-jin Lee !

thank you very much for your acknowledgment regarding estimation of lambda_z !

you may think on using the function lee in the R package PK for estimation of lambda_z. you may adopt the lee approach to estimate lambda_z for extravascual administered drugs. I think by calling the function lee with a subset of the data (e.g. the period from Tmax to Tlast) should provide estimates for lambda_z.

what do you think?

best regards

martin

PS.: note that we used log10 - transformed values for estimation of intitial and terminal half-life after IV bolus administration. we used the log10 transformation in accordance to the orginal paper of Lee et. al (1990). in the case that you are interested in estimation of lambda_z for estimation of AUC from 0 to infinity (extrapolated area) you have to use the ln transformation otherwise your AUC from 0 to infinity is biased.

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