Outdated and wrong answers [General Sta­tis­tics]

posted by mittyri – Russia, 2023-10-05 22:34 (147 d 01:33 ago) – Posting: # 23743
Views: 1,455

Dear Achievewin!

15-20 years ago the answers could be the following
  1. How to measure carry-over (any particular PK parameters or in vitro measures?)
    Usually we say that unequal carryover exists, when the p-value for Sequence effect in ANOVA is less than 5% for any of parameters of interest.
    We say that equal carryover exists, when the p-value for Period effect in ANOVA is less than 5%.


  2. How to assess equal or unequal carryover?
    See above

  3. Differences in 1st order or other order carry-over

    Something like this (one carryover effect overrides the previous one)
    https://online.stat.psu.edu/stat509/lesson/15/15.5

  4. Is there a cut-off to call negligible carry-over
    If the sequence effect is more than 5%: the carry-over effect is negligible.

  5. What are the statistical tests to call it a unequal carry-over or no un-equal carry-over.
    ANOVA F test

  6. How to factor or apply any corrections of observed carry-over in BE and RSABE calculations?
    Apply BE for the 1st period only.


Please don't get me wrong. These answers could be correct decades ago.

Kind regards,
Mittyri

Complete thread:

UA Flag
Activity
 Admin contact
22,916 posts in 4,807 threads, 1,645 registered users;
30 visitors (0 registered, 30 guests [including 11 identified bots]).
Forum time: 23:08 CET (Europe/Vienna)

Nothing shocks me. I’m a scientist.    Harrison Ford (as Indiana Jones)

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5