Bioequivalence and Bioavailability Forum

Outdated and wrong answers [General Statistics]

posted by mittyri – Russia, 2023-10-05 22:34 (584 d 05:38 ago) – Posting: # 23743
Views: 4,918

Dear Achievewin!

15-20 years ago the answers could be the following

How to measure carry-over (any particular PK parameters or in vitro measures?)
Usually we say that unequal carryover exists, when the p-value for Sequence effect in ANOVA is less than 5% for any of parameters of interest. We say that equal carryover exists, when the p-value for Period effect in ANOVA is less than 5%.
How to assess equal or unequal carryover?
See above
Differences in 1st order or other order carry-over

Something like this (one carryover effect overrides the previous one)
https://online.stat.psu.edu/stat509/lesson/15/15.5
Is there a cut-off to call negligible carry-over
If the sequence effect is more than 5%: the carry-over effect is negligible.
What are the statistical tests to call it a unequal carry-over or no un-equal carry-over.
ANOVA F test
How to factor or apply any corrections of observed carry-over in BE and RSABE calculations?
Apply BE for the 1st period only.

Please don't get me wrong. These answers could be correct decades ago.

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Kind regards,
Mittyri