Bioequivalence and Bioavailability Forum • RSABE with two test products: Sample size?

RSABE with two test products: Sample size? [Design Issues]

posted by Helmut – Vienna, Austria, 2023-08-23 13:51 (418 d 18:29 ago) – Posting: # 23707
Views: 3,191

Hi Darborn,

❝ I tried to read your article about replicate crossover, and now I know it is so called "incomplete block design" (am I right?).

You are. Specifically it is the result of excluding treatments.

❝ However, the true nightmare comes, how can I estimate the sample size required for a power of 80%. :confused:

❝ I guess that using the design of 2x3x3 or 2x2x4 in powerTOST is a big NO… :no:

You would need the function sampleN.RSABE(), but the argument design = "2x4x4" is not implemented. Sorry.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes