Bioequivalence and Bioavailability Forum • RSABE with two test products: Sample size?

RSABE with two test products: Sample size? [Design Issues]

posted by Helmut – Vienna, Austria, 2023-08-23 13:51 (97 d 20:29 ago) – Posting: # 23707
Views: 868

Hi Darborn,

❝ I tried to read your article about replicate crossover, and now I know it is so called "incomplete block design" (am I right?).

You are. Specifically it is the result of excluding treatments.

❝ However, the true nightmare comes, how can I estimate the sample size required for a power of 80%. :confused:

❝ I guess that using the design of 2x3x3 or 2x2x4 in powerTOST is a big NO… :no:

You would need the function sampleN.RSABE(), but the argument design = "2x4x4" is not implemented. Sorry.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Science Quotes

crossover design when use RSABE with two test products Darborn 2023-08-22 02:24 [Design Issues]
- RSABE with two test products Helmut 2023-08-23 10:01
  - RSABE with two test products Darborn 2023-08-23 11:13
    - RSABE with two test products: Sample size?Helmut 2023-08-23 11:51
      - RSABE with two test products: Sample size? Darborn 2023-08-30 08:07