crossover design when use RSABE with two test products [Design Issues]
Normally we use 2x3x3 or 2x2x4 replicated design for RSABE, but it needs only one test drug.
When design a crossover trial with two test drug (or one ODT given with/without water), I run into confusion about how to give a balanced design for the trial.
Furthermore, which make things even worse, I always get confused by "variance-balanced" and "carryover-balance" design.
I came out with the following design, but I'm not sure if it is suitable to use when analyzed with FDA RSABE approach.
T1 R T2 R
R T1 R T2
T2 R T1 R
R T2 R T1
Edit: Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]
- crossover design when use RSABE with two test productsDarborn 2023-08-22 02:24 [Design Issues]