heteroscedasticity in RSABE (and ABEL) [RSABE / ABEL]
❝ If the RSABE method is performed on the highly variable drug with the 4-way crossover design (not the NTI drug), is the homoscedasticity assumption always holden?
❝ And I think if a 3-way crossover design is used, there is no way to assume the homoscedasticity since the test drug is administered once and we can not calculate the WSV of the test drug.
❝ A further question is, when do we assume the reference and test product have equal variances, i.e. CVwT ≡ CVwR? And why?
If the true CVwT < CVwR, the study will be overpowered, which is economically and ethically questionable. If it will be the other way around, bad luck. See also this article about heteroscedasticity in RSABE and that one for ABEL.
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
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- homoscedasticity assumption in RSABE method WinnieH 2023-08-18 08:57 [RSABE / ABEL]