IVIVC input data [Dissolution / BCS / IVIVC]

posted by Porfirio – 2023-07-18 19:55 (647 d 11:09 ago) – Posting: # 23674
Views: 4,464

Hello everyone!
I am a beginner on the subject about IVIVC and I have plenty questions. Can somebody help me?
Coul you recommend me a step by step course to develop ivivc?

I´m trying to develop an example of IVIVC. I have in vitro and in vivo data for an intermediate release (InR) formulation, a slow release (SR), immediate release (IR) and the reference formulation (target). I only have in vitro data of the “test” formulation and I wan to predict its pharmacokinetic parameters. I tried to do it but something was wrong (see images below).
  1. I read in a forum that UIR depends on the number of compartments, but what exactly does it mean? Should I always put 3?
  2. In the validation which one should I put as external or internal?
  3. How do I know if I should put the weibull function or the double weibull function (for example)? Is the fit bond performed before or does the software also perform it?
  4. For weighting, how do I know which one to choose?
[image]
[image]
My apologies, I think there are many questions, I hope you can help me with some. It is very important for me.

Thaks
Best regards

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,669 registered users;
29 visitors (0 registered, 29 guests [including 7 identified bots]).
Forum time: 07:05 CEST (Europe/Vienna)

A drug is that substance which, when injected into a rat,
will produce a scientific report.    Anonymous

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5