IVIVC input data [Dissolution / BCS / IVIVC]

posted by Porfirio – 2023-07-18 19:55 (338 d 00:50 ago) – Posting: # 23674
Views: 2,334

Hello everyone!
I am a beginner on the subject about IVIVC and I have plenty questions. Can somebody help me?
Coul you recommend me a step by step course to develop ivivc?

I´m trying to develop an example of IVIVC. I have in vitro and in vivo data for an intermediate release (InR) formulation, a slow release (SR), immediate release (IR) and the reference formulation (target). I only have in vitro data of the “test” formulation and I wan to predict its pharmacokinetic parameters. I tried to do it but something was wrong (see images below).
  1. I read in a forum that UIR depends on the number of compartments, but what exactly does it mean? Should I always put 3?
  2. In the validation which one should I put as external or internal?
  3. How do I know if I should put the weibull function or the double weibull function (for example)? Is the fit bond performed before or does the software also perform it?
  4. For weighting, how do I know which one to choose?
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My apologies, I think there are many questions, I hope you can help me with some. It is very important for me.

Thaks
Best regards

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