‘dlat’ for 3-period full replicate? [RSABE / ABEL]

posted by mittyri – Russia, 2023-07-07 18:04 (381 d 09:59 ago) – Posting: # 23661
Views: 2,350

Hi Helmut!

❝ I have a problem (both in Phoenix/WinNonlin, R, and – likely – in SAS as well). To calculate swR the FDA wants a linear model (in SAS-lingo proc glm) of repeated reference data with subject as a factor. However, in a 3-period full replicate they are all in one sequence and the model collapses. Now what?

you discovered another point for a lecture ;-)
So the problem is here
proc glm data=scavbe;
  class seq;
  model dlat=seq;
  ods output overallanova=dglm1;
  ods output NObs=dglm3;
  title1 'scaled average BE';
run;


I would look at the original formula

\(s_\text{wR}^2=\Large\frac{\sum\limits_{i=1}^{m}\sum_\limits{j=1}^{n_i}\left(D_{ij}-\overline{D}_{i\,\cdot}\right)^2}{2\left(n-m\right)}\)

So it is impossible to get D for `TRT` sequence. Could we just omit one sequence here?

Kind regards,
Mittyri

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