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Registerany SAS or R-macro for 3 period two sequence RSABEIs [RSABE / ABEL]
Hi
Is there any SAS or R-Macro or program for performing RSABR in a 3-period 2-sequnce balanced replicate design? or how a doubt given below can be clarified?
A 3-period, 2-sequence (TRR or RTT) is proposed assuming it is a balanced design! how to clarify the reference-scaled average bioequivalence approach will be applied to the proposed sequences.
Thinking Rationale: was that the design was preferred in the current statistical approaches guidance current SAS macros ignore any missing sequence and provide RSABE conclusions with existing macros and secondly any unknown carry-over effect is best addressed in the current sequence by balance effect.
Any input is appreciated.
Is there any SAS or R-Macro or program for performing RSABR in a 3-period 2-sequnce balanced replicate design? or how a doubt given below can be clarified?
A 3-period, 2-sequence (TRR or RTT) is proposed assuming it is a balanced design! how to clarify the reference-scaled average bioequivalence approach will be applied to the proposed sequences.
Thinking Rationale: was that the design was preferred in the current statistical approaches guidance current SAS macros ignore any missing sequence and provide RSABE conclusions with existing macros and secondly any unknown carry-over effect is best addressed in the current sequence by balance effect.
Any input is appreciated.
Complete thread:
- any SAS or R-macro for 3 period two sequence RSABEIsAchievwin 2023-07-05 18:38 [RSABE / ABEL]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Use the one for TRTR | RTRT Helmut 2023-07-06 08:46
- RSABE R coded by Detlew mittyri 2023-07-06 14:07
- ‘dlat’ for 3-period full replicate? Helmut 2023-07-07 14:41
- ‘dlat’ for 3-period full replicate? mittyri 2023-07-07 16:04
- Likely wrong workaround? Helmut 2023-07-07 20:06
- a bit corrected workaround mittyri 2023-07-07 22:52
- THX! Another attempt… Helmut 2023-07-08 12:15
- complete.cases for dlat and ilat? mittyri 2023-07-09 21:45
- a bit corrected workaround Achievwin 2023-07-10 20:43
- THX! Another attempt… Helmut 2023-07-08 12:15
- a bit corrected workaround mittyri 2023-07-07 22:52
- Likely wrong workaround? Helmut 2023-07-07 20:06
- ‘dlat’ for 3-period full replicate? mittyri 2023-07-07 16:04
- ‘dlat’ for 3-period full replicate? Helmut 2023-07-07 14:41
- RSABE R coded by Detlew mittyri 2023-07-06 14:07
- Use the one for TRTR | RTRT Helmut 2023-07-06 08:46
Ing. Helmut Schütz