any SAS or R-macro for 3 period two sequence RSABEIs [RSABE / ABEL]

posted by Achievwin – US, 2023-07-05 20:38 (146 d 11:09 ago) – Posting: # 23655
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Is there any SAS or R-Macro or program for performing RSABR in a 3-period 2-sequnce balanced replicate design? or how a doubt given below can be clarified?

A 3-period, 2-sequence (TRR or RTT) is proposed assuming it is a balanced design! how to clarify the reference-scaled average bioequivalence approach will be applied to the proposed sequences.

Thinking Rationale: was that the design was preferred in the current statistical approaches guidance current SAS macros ignore any missing sequence and provide RSABE conclusions with existing macros and secondly any unknown carry-over effect is best addressed in the current sequence by balance effect.

Any input is appreciated.

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