Inaccuracy, precision acc. to IUPAC [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2023-06-30 13:33 (328 d 17:27 ago) – Posting: # 23637
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Hi Avinash,

not answering you question but a general comment. IMHO, the confusion in terminology (also in other bioanalytical guidelines) is probably caused by only a few analytical chemists (for ICH M10 just one?) involved.*

Accuracy is qualitative. We want that our result have small inaccuracy (which is quantitative). The ±15% (±20% at the LLOQ) ‘accuracy‘ stated in the guideline(s) is sloppy terminology. SCNR. I’m fine with 85–115% (80–120% at the LLOQ) of the true value or, if you prefer, ±15% (±20% at the LLOQ) inaccuracy. The term ‘non-accuracy’ is an invention of ICH.

The proper terms are unambiguously defined by the ‘International Union of Pure and Applied Chemistry’ (founded 1919!) in its ‘Golden Book’:


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