Bioequivalence and Bioavailability Forum • tmax ≠ Cmax 🙂

tmax ≠ Cmax 🙂 [NCA / SHAM]

posted by Imph – 2023-06-27 19:33 (678 d 18:40 ago) – Posting: # 23630
Views: 3,333

❝ ❝ Tmax: Time of maximum observed concentration. For non-steady-state data, the entire curve is considered. If the maximum observed concentration is not unique, then the first maximum is used

❝

❝ Sure, but you were talking about C_max – not t_max. That’s how it is implemented in all software I know.

Yes but the Cmax was defined accordingly:

Cmax: Maximum observed concentration, occurring at time Tmax, as defined above.

When reading this, we can easily think that the software would take the first peak as Cmax.

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

concentration-time profile with two peaks or more Imph 2023-06-27 13:06 [NCA / SHAM]
- concentration-time profile with two peaks or more dshah 2023-06-27 13:13
  - concentration-time profile with two peaks or more Imph 2023-06-27 13:26
    - What does ‘max’ in Cmax mean? Helmut 2023-06-27 13:44
      - What does ‘max’ in Cmax mean? Imph 2023-06-27 15:18
        
        Which software? Helmut 2023-06-27 15:24
        
        Which software? Imph 2023-06-27 16:56
        
        tmax ≠ Cmax 🙂 Helmut 2023-06-27 17:03
        
        tmax ≠ Cmax 🙂Imph 2023-06-27 17:33
        
        tmax ≠ Cmax 🙂 BEQool 2023-06-27 18:25