tmax ≠ Cmax 🙂 [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2023-06-27 19:03 (154 d 11:59 ago) – Posting: # 23629
Views: 813

Hi Imph,

❝ In the WinNonlin guide, this is how tmax is defined:

❝ Tmax: Time of maximum observed concentration. For non-steady-state data, the entire curve is considered. If the maximum observed concentration is not unique, then the first maximum is used

Sure, but you were talking about Cmax – not tmax. That’s how it is implemented in all software I know.
During a training a smart-ass said “That’s all wrong! If there are identical maxima, tmax should be reported as the median of observed times.” I think that’s a rather academic question. How likely is it to have exactly (‼) the same concentrations?

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