Bioequivalence and Bioavailability Forum • tmax ≠ Cmax 🙂

tmax ≠ Cmax 🙂 [NCA / SHAM]

posted by Helmut – Vienna, Austria, 2023-06-27 19:03 (96 d 10:40 ago) – Posting: # 23629
Views: 656

Hi Imph,

❝ In the WinNonlin guide, this is how tmax is defined:

❝

❝ Tmax: Time of maximum observed concentration. For non-steady-state data, the entire curve is considered. If the maximum observed concentration is not unique, then the first maximum is used

Sure, but you were talking about C_max – not t_max. That’s how it is implemented in all software I know.
During a training a smart-ass said “That’s all wrong! If there are identical maxima, t_max should be reported as the median of observed times.” I think that’s a rather academic question. How likely is it to have exactly (‼) the same concentrations?

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Complete thread:

concentration-time profile with two peaks or more Imph 2023-06-27 13:06 [NCA / SHAM]
- concentration-time profile with two peaks or more dshah 2023-06-27 13:13
  - concentration-time profile with two peaks or more Imph 2023-06-27 13:26
    - What does ‘max’ in Cmax mean? Helmut 2023-06-27 13:44
      - What does ‘max’ in Cmax mean? Imph 2023-06-27 15:18
        
        Which software? Helmut 2023-06-27 15:24
        
        Which software? Imph 2023-06-27 16:56
        
        tmax ≠ Cmax 🙂Helmut 2023-06-27 17:03
        
        tmax ≠ Cmax 🙂 Imph 2023-06-27 17:33
        
        tmax ≠ Cmax 🙂 BEQool 2023-06-27 18:25