No ‘R1’ and ‘R2’ in replicate designs [General Statistics]
Sorry, because I am lego and I can´t understand all correctly.
❝ There is no ‘R1’ and ‘R2’, only one R repeatedly administered in the sequences in different periods. Say, the sequences are
TRR | RTR | RRT. Did the CRO call the first administration in each sequence R1 and the second R2 (while dropping T)?
❝ As said above, such a ‘comparison’ will not work.
❝ You tried
CI2CV(lower=0.8731, upper=1.4057, design="2x2x2", n=40), right? That’s not what you have. After recoding (wild guess) you have an Incomplete Block Design. Other degrees of freedom,
❝ These formulas are for a 2×2×2 crossover and are also implemented in
CI2CV(). But again, there is only one R. A ‘PE’ and ‘CI’ doesn’t make sense.
❝ You can only calculate the CVwR according to the EMA’s or the FDA’s models. The results will be similar, though quite often the one of the FDA is a bit smaller.
Edit: Standard quotes restored; see also this post #8. [Helmut]
- Calculation of PE and 90% CI Brus 2023-06-14 16:34 [General Statistics]