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Registerwithin subject standard deviation in fully replicate design if carry over effect is present [General Statistics]
Hello Ankit!
If by day 4- conc. are LT 5% of Cmax- then what is your half life? Why do you want to measure it for 120 days and the burst release doesn't have any toxicity impact? If even product name can not be shared- then it is difficult to be answered from very few details.
Regards,
Divyen
❝ Cmax is due to the burst phase of release from the formulation however the plasma concentration required to produce therapeutic effect is very low i.e. < 5 % of Cmax and it remains in therapeutic range from Day 4 to 120 due to slow release of the product. It provides therapeutic effect for 4 months and then new injection has to be taken on day 120.
If by day 4- conc. are LT 5% of Cmax- then what is your half life? Why do you want to measure it for 120 days and the burst release doesn't have any toxicity impact? If even product name can not be shared- then it is difficult to be answered from very few details.
Regards,
Divyen
Complete thread:
- within subject standard deviation in fully replicate design if carry over effect is present Ankit Parikh 2023-06-08 13:54 [General Statistics]
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- within subject standard deviation in fully replicate design if carry over effect is present dshah 2023-06-08 16:35
- within subject standard deviation in fully replicate design if carry over effect is present Ankit Parikh 2023-06-09 07:15
- within subject standard deviation in fully replicate design if carry over effect is presentdshah 2023-06-14 09:26
- within subject standard deviation in fully replicate design if carry over effect is present Ankit Parikh 2023-06-14 09:33
- within subject standard deviation in fully replicate design if carry over effect is present dshah 2023-06-14 10:37
- within subject standard deviation in fully replicate design if carry over effect is present Ankit Parikh 2023-06-14 09:33
- within subject standard deviation in fully replicate design if carry over effect is presentdshah 2023-06-14 09:26
- within subject standard deviation in fully replicate design if carry over effect is present Ankit Parikh 2023-06-09 07:15
- within subject standard deviation in fully replicate design if carry over effect is present dshah 2023-06-08 16:35
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