within subject standard deviation in fully replicate design if carry over effect is present [General Sta­tis­tics]

posted by Ankit Parikh – India, 2023-06-09 09:15 (345 d 07:19 ago) – Posting: # 23584
Views: 1,329

Hello Divyen!

After dosing, the plasma concentration reaches Cmax in about 4 hours and comes down below 5 % of Cmax in 2-3 days and remains stable from day 4 to 120 and is also the pre-dose concentration for subsequent period/s.

❝ I am not getting you. By 2-3 days, the concentration are below 5% of Cmax and then stable from day 4 to 120?

❝ So by 2-3 days, almost all the drug is eliminated? What is the average half life and range of half life for drug?

Cmax is due to the burst phase of release from the formulation however the plasma concentration required to produce therapeutic effect is very low i.e. < 5 % of Cmax and it remains in therapeutic range from Day 4 to 120 due to slow release of the product. It provides therapeutic effect for 4 months and then new injection has to be taken on day 120.


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