posted by Helmut Homepage – Vienna, Austria, 2023-06-07 12:22 (116 d 04:13 ago) – Posting: # 23579
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Hi Brus,

❝ But nothing is said about the option full-replicate 3-ways, 2-sequences: TRT / RTR,……

Stupid enough. We may run into trouble if we have to assess the study in a partial replicate design for ABE because \(\small{s_\text{wR} < 0.294}\). See this article. At a recent webinar I tried to ask Donald Schuirmann. Was ignored…

❝ … which does seem to be included in the guideline Statistical Approaches to Establishing Bioequivalence.

Pragmatic: This one is the newest one. ;-)

❝ Does this mean that this design can no longer be used?

I don’t see any reason for not doing so. Why should we use an inferior method in lieu of a better one? If in doubt, initiate a controlled correspondence.

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