Bioequivalence and Bioavailability Forum • total (pooled) variance: examples

total (pooled) variance: examples [Power / Sample Size]

posted by BEQool – Slovenia, 2023-04-18 11:59 (167 d 05:42 ago) – Posting: # 23525
Views: 1,471

Hello!

It has been a long time since this was posted but I have been looking for ways to calculate inter-subject CV and I saw these following equations:

❝ […] ❝ From a 2×2×2 crossover design we may estimate

intra-subject variability as
❝ \(CV_e(\%)=100\sqrt{e^{MS_e}-1}\)
❝
inter-subject variability as
❝ \(CV_s(\%)=100\sqrt{e^{(MS_s{\color{Red} -}ME_e)/2}-1}\)
❝
total (pooled) variability as
❝ \(CV_p(\%)=100\sqrt{e^{(MS_s{\color{Red} +}ME_e)/2}-1}\)

And since it was mentioned that we may estimate CVs with these equations from a 2x2x2 crossover study I am curious if this equations for CVs also apply for other higher order designs?

Best regards
BEQool

Complete thread:

Sample size estimation for parallel design Nav Coelho 2007-07-20 16:14 [Power / Sample Size]
- Parallel designs (total variance) Helmut 2007-07-20 16:29
  - Parallel designs (total variance) Nav Coelho 2007-07-20 18:38
    - CV-intra # 60% CV-inter Helmut 2007-07-22 01:17
    - total (pooled) variance: examples Helmut 2007-07-23 17:44
      - total (pooled) variance: examples Nav Coelho 2007-07-23 19:58
      - total (pooled) variance: examplesBEQool 2023-04-18 09:59
        
        Higher-Order Crossovers Helmut 2023-04-20 10:19
        
        Higher-Order Crossovers BEQool 2023-04-21 07:53
        
        total (pooled) variance: examples zizou 2023-04-21 21:23
        
        total (pooled) variance: examples BEQool 2023-04-22 18:20
        
        total (pooled) variance: examples zizou 2023-04-22 21:06
        
        total (pooled) variance: examples BEQool 2023-04-25 10:57
        
        total (pooled) variance: examples zizou 2023-04-25 22:43
        
        total (pooled) variance: examples BEQool 2023-05-04 08:17
- Sample size estimation for parallel design Dipesh Jayswal 2007-07-24 08:52