CI.BE in PowerTOST [🇷 for BE/BA]

posted by BEQool  – 2023-03-31 12:05 (333 d 03:02 ago) – Posting: # 23518
Views: 1,391

Hello everyone!

I am a complete beginner in BEQ field and lately I have been going through this forum a lot and have learned so much and I would like to thank you all for contributing to thorough explanations and interesting discussions.

Regarding my question, I was calculating confidence intervals in R using package PowerTOST and function CI.BE and I think I have noticed a minor mistake in CI calculations when having unbalanced design with odd total number of subjects without defining number of subjects in each sequence. If I am not mistaken, in this case the program incorrectly calculates CI assuming balanced design with half (0.5) of a subject in each sequence and doesnt assume an unbalanced design with small imbalanced as it does in other functions (for example when calculating power using power.TOST).

An example:
CI.BE(pe=1.0659, CV=0.1539, n=27)
    lower     upper
0.9927168 1.1444783

CI.BE(pe=1.0659, CV=0.1539, n=c(13.5,13.5))
    lower     upper
0.9927168 1.1444783

CI.BE(pe=1.0659, CV=0.1539, n=c(14,13))
    lower     upper
0.9926683 1.1445341


Notice that CI for n=27 are the same as for n=c(13.5,13.5), however the correct CI should probably be the same as for n=c(14,13). Not big of a difference, however it could be relevant in some cases?

I am sorry if this has already been discussed before, I went through forum and havent found anything relevant.


Best regards
BEQool

Complete thread:

UA Flag
Activity
 Admin contact
22,912 posts in 4,806 threads, 1,635 registered users;
33 visitors (0 registered, 33 guests [including 5 identified bots]).
Forum time: 14:08 CET (Europe/Vienna)

It is the peculiar and perpetual error of the human understanding
to be more moved and excited by affirmatives than negatives.    Francis Bacon

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5