Full Replicate with 3 periods [Design Issues]

posted by mittyri – Russia, 2023-03-28 00:16 (334 d 16:44 ago) – Posting: # 23514
Views: 2,095

Dear Achievwin!

❝ Can TRT, RTR be called two sequence full replicate in three way cross over?

I would say in three periods. For me 'a way' is closer to the sequence (subject's way :-D). But that's just my feeling, I see many people are using it, so your wording is rather correct.

❝ can it be a substitute for RTRT or TRTR, or TTRR or RRTT (in four period fully replicated design)?

Hey! Look at the fresh FDA draft
Bloody partial replicate goes away and is being substituted to that design in GL. I would opt for it.

Kind regards,

Complete thread:

UA Flag
 Admin contact
22,911 posts in 4,806 threads, 1,635 registered users;
27 visitors (0 registered, 27 guests [including 5 identified bots]).
Forum time: 16:01 CET (Europe/Vienna)

The history of statistics is like a telephone directory:
the plot is boring, full of numbers and the cast is endless.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz