Upper confidence bound and confidence interval of RSABE [RSABE / ABEL]

posted by WinnieH – Sweden, 2023-03-21 11:58 (192 d 15:58 ago) – Posting: # 23507
Views: 666

Hi all,

By reading this nice lecture: Page 23- 25, I get more clear idea about the 95% upper confidence bound concept. Many thanks!

Here I have one following question (maybe very naive), I was wondering that why we need rearrange the SABE model
ln(0.8)*sigmaW/sigma0 <= muT-muR <= ln(1.25)*sigmaW/sigma0
to the linear form
and then calculate the 95% CI from the linear form? What will happen if we use the regular unscaled BE way to calculate 90% CI of muT-muR and compare with the scaled BE limits?

Thank you very much!

Best regards,

Complete thread:

UA Flag
 Admin contact
22,763 posts in 4,775 threads, 1,627 registered users;
21 visitors (0 registered, 21 guests [including 7 identified bots]).
Forum time: 04:57 CEST (Europe/Vienna)

We should not speak so that it is possible
for the audience to understand us,
but so that it is impossible
for them to misunderstand us.    Quintilian

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz