Definition of Full Replicate [Design Issues]

posted by Brus – Spain, 2023-03-14 11:10 (17 d 18:19 ago) – Posting: # 23498
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Dear Sereng,

From my understanding, this is not a replicate study. 4-ways is not always a replicate. There can be 4 periods but with 4 different formulations, or in different administration conditions, and in those cases it would not be a "full replicate". In your case, according to my humble opinion it is not a "full replicate" since they are administered in different conditions (fast VS fed). In your case, I think it would be more accurate to call it "4-ways food effects". At least in our own previous experiences, this is the way we have approached it.

Best regards,

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