average bioequivalence: MLE vs. REML [General Sta­tis­tics]

posted by Mahmoud  – Jordan, 2023-03-11 13:21 (463 d 15:33 ago) – Posting: # 23493
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Dear All
In bioequivalence 2x2 (TR,TR) 3x3 ( TRR,RRT,RTR) and 2x4(TRTR,RTRT)
for the statistical anaylsis based code SAS

PROC MIXED;
CLASSES SEQ SUBJ PER TRT; 1077
MODEL Y = SEQ PER TRT/ DDFM=SATTERTH; 1078
RANDOM TRT/TYPE=FA0(2) SUB=SUBJ G; 1079
REPEATED/GRP=TRT SUB=SUBJ; 1080
ESTIMATE 'T vs. R' TRT 1 -1/CL ALPHA=0.1;
run;
By simulation study I found that

MLE method better when number of fixed effects ≤ 4.
REML method better when number of fixed effects > 4.


Edit: Category and subject line changed; see also this post #1[Helmut]

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