Sample size for replicate crossover studies [Power / Sample Size]

posted by Imph – Algeria, 2023-03-06 15:29 (95 d 00:25 ago) – Posting: # 23487
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For sample size calculation in the case of full replicate design using R software, when specifying the 2x2x4 in the script, do we get the same sample size whether the design is to be : TRTR|RTRT or TRRT|RTTR. And same question for the partially replicated design TRT|RTR vs TRR|RTT.

In the same way for manual computation, can we use the sample size formula presented by CHOW for the TRRT|RTTR design to calculate the sample size for TRTR|RTRT design. And same question, could the sample size formula of TRR|RTT design be used for TRT|RTR design.

Thanks a lot.

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