## Questions on understanding the 4-way RSABE method SAS code [RSABE / ABEL]

Hi Winnie,

I don’t speak SAS but isn’t it a restricted maximum likelihood estimate?

I’m short in time right now; compare it to Detlew’s script in base R.

Haha, ‘the unknown x’. I’m aware of only one reference,* which is – regrettably – not in the public domain.

❝ I am a new learner and I am trying on understanding the 4-way RSABE method SAS code provided by FDA: […]

❝ I found some discussion about the S2wr and it is really helpful to me. About the ilat, my understanding is that the model is a simple linear model and the estimate is the least square mean.

I don’t speak SAS but isn’t it a restricted maximum likelihood estimate?

❝ My R code example is as follows: […]

I’m short in time right now; compare it to Detlew’s script in base R.

❝ My question is 1) how to interpret x and critbound=(x+y)+sqrt(((boundx-x)**2)+((boundy-y)**2))? Is there any related explanation about them?

Haha, ‘the unknown x’. I’m aware of only one reference,* which is – regrettably – not in the public domain.

- The statistical approach we use is very similar to that proposed by Tothfalusi,

Endrenyi,*et al.*2001, with a minor difference (use of an unbiased estimator for

(*μ*_{T}–*μ*_{R})^{2}).

- Schuirmann D.
*U.S. FDA Perspective: Statistical Aspects of OGD’s Approach to Bioequivalence (BE) Assessment for Highly Variable Drugs.*Presentation at the 2^{nd}conference of The Global Harmonisation Initiative (GBHI). Rockville. September 15–16, 2016.

—

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

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*Dif-tor heh smusma*🖖🏼 Довге життя Україна!_{}Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

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### Complete thread:

- Questions on understanding the 4-way RSABE method SAS code WinnieH 2023-01-04 13:33 [RSABE / ABEL]
- Questions on understanding the 4-way RSABE method SAS codeHelmut 2023-01-04 14:02
- Questions on understanding the 4-way RSABE method SAS code WinnieH 2023-01-04 15:12

- Questions on understanding the 4-way RSABE method SAS codeHelmut 2023-01-04 14:02