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RegisterWashout based on mean ± SD of t½ [Design Issues]
Hi,
Thank you very much for your valuable informations.
I would like to know if this method can be applied to each pharmacokinetic measurement, for example to determine the duration of the sampling (5 x t1/2) or to calculate the predose limit of 5% Cmax when the Cmax is provided in the literature under mean+/-SD.
Why plan for 95% coverage (z0.95 = 1.96), is it related to alpha =5%.
In the reference you gave, a normal distribution is assumed, but pharmacokinetic measurements do not generally follow a normal distribution but a log-normal one. Does this method still apply?
Thank you verry much.
Thank you very much for your valuable informations.
I would like to know if this method can be applied to each pharmacokinetic measurement, for example to determine the duration of the sampling (5 x t1/2) or to calculate the predose limit of 5% Cmax when the Cmax is provided in the literature under mean+/-SD.
Why plan for 95% coverage (z0.95 = 1.96), is it related to alpha =5%.
In the reference you gave, a normal distribution is assumed, but pharmacokinetic measurements do not generally follow a normal distribution but a log-normal one. Does this method still apply?
Thank you verry much.
Complete thread:
- Washout based on mean ± SD of t½ Imph 2022-09-25 13:52 [Design Issues]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Washout based on mean ± SD of t½ Helmut 2022-09-25 16:08
- Washout based on mean ± SD of t½Imph 2022-09-26 15:24
- Washout based on mean ± SD of t½ Shuanghe 2022-09-26 17:34
- Washout based on mean ± SD of t½ Helmut 2022-09-26 17:35
- If you have data… Helmut 2022-09-27 11:52
- If you have data… Imph 2022-10-25 09:21
- Washout based on mean ± SD of t½ Imph 2023-05-26 23:31
- Washout based on mean ± SD of t½ Helmut 2023-05-27 06:52
- Washout based on mean ± SD of t½ Imph 2023-05-27 08:36
- Washout based on mean ± SD of t½ Helmut 2023-05-27 06:52
- Washout based on mean ± SD of t½Imph 2022-09-26 15:24
- Washout based on mean ± SD of t½ Helmut 2022-09-25 16:08
Ing. Helmut Schütz