Washout based on mean ± SD of t½ [Design Issues]

posted by Imph – Algeria, 2022-09-26 17:24 (70 d 04:57 ago) – Posting: # 23320
Views: 718


Thank you very much for your valuable informations.

I would like to know if this method can be applied to each pharmacokinetic measurement, for example to determine the duration of the sampling (5 x t1/2) or to calculate the predose limit of 5% Cmax when the Cmax is provided in the literature under mean+/-SD.

Why plan for 95% coverage (z0.95 = 1.96), is it related to alpha =5%.

In the reference you gave, a normal distribution is assumed, but pharmacokinetic measurements do not generally follow a normal distribution but a log-normal one. Does this method still apply?

Thank you verry much.

Complete thread:

UA Flag
 Admin contact
22,428 posts in 4,694 threads, 1,598 registered users;
17 visitors (0 registered, 17 guests [including 13 identified bots]).
Forum time: 21:22 CET (Europe/Vienna)

Statistics is the art of never having to say you’re wrong.
Variance is what any two statisticians are at.    C.J. Bradfield

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz