Bioequivalence and Bioavailability Forum • Washout based on mean ± SD of t½

Washout based on mean ± SD of t½ [Design Issues]

posted by Helmut – Vienna, Austria, 2022-09-25 18:08 (576 d 08:47 ago) – Posting: # 23319
Views: 2,843

Hi Imph,

❝ Is it right to do "7 x t1/2 mean" without taking into consideration the SD?

That’s extremely risky. You may see residual concentrations in subjects with a half life longer than the reported mean and have to exclude them to avoid carryover (i.e., if the predose concentration is >5% C_max).

See this presentation (slides 64/65).

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Complete thread:

Washout based on mean ± SD of t½ Imph 2022-09-25 13:52 [Design Issues]
- Washout based on mean ± SD of t½Helmut 2022-09-25 16:08
  - Washout based on mean ± SD of t½ Imph 2022-09-26 15:24
    - Washout based on mean ± SD of t½ Shuanghe 2022-09-26 17:34
    - Washout based on mean ± SD of t½ Helmut 2022-09-26 17:35
    - If you have data… Helmut 2022-09-27 11:52
      - If you have data… Imph 2022-10-25 09:21
  - Washout based on mean ± SD of t½ Imph 2023-05-26 23:31
    - Washout based on mean ± SD of t½ Helmut 2023-05-27 06:52
      - Washout based on mean ± SD of t½ Imph 2023-05-27 08:36