Washout based on mean ± SD of t½ [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2022-09-25 18:08 (627 d 23:35 ago) – Posting: # 23319
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Hi Imph,

❝ Is it right to do "7 x t1/2 mean" without taking into consideration the SD?


That’s extremely risky. You may see residual concentrations in subjects with a half life longer than the reported mean and have to exclude them to avoid carryover (i.e., if the predose concentration is >5% Cmax).

See this presentation (slides 64/65).

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