R code for Average BE or parallel design N com­pu­ta­tions [🇷 for BE/BA]

posted by Achievwin – US, 2022-09-16 06:31 (142 d 21:31 ago) – Posting: # 23300
Views: 1,381

Dear All:

R PowerTOST has a neat code that gives tabular listing of N and power attained for Scaled ABE using the macro below.

Is there a similar code for ABE for 2x2 or parallel design studies. Any help is much appreciated.
(may be a simple thing but I don't know)

Thanks and regards,

Achievwin

sampleN.RSABE(alpha = 0.05, targetpower = 0.80, theta0 = 0.9, theta1 = 0.8, theta2 = 1.25, CV = c(0.46, 0.46),
design = c("2x2x4"), regulator = c("FDA"),
nsims = 1e+05, nstart = 24, imax=100,
print = TRUE, details = TRUE, setseed=TRUE).
---------------------------------------------
Study design: 2x2x3 (3 period full replicate)
log-transformed data (multiplicative model)
1e+05 studies for each step simulated.
alpha  = 0.05, target power = 0.9
CVw(T) = 0.46; CVw(R) = 0.46
True ratio = 0.93
ABE limits / PE constraints = 0.8 ... 1.25
FDA regulatory settings
- CVswitch            = 0.3
- regulatory constant = 0.8925742
- pe constraint applied
Sample size search
 n     power
24   0.72529
26   0.76284
28   0.79686
30   0.82498
32   0.84757
34   0.86782
36   0.88550
38   0.89948
40   0.91323

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