Bioequivalence and Bioavailability Forum • AND or OR, that’s the question

AND or OR, that’s the question [Power / Sample Size]

posted by chrisk – 2022-08-10 19:46 (618 d 00:30 ago) – Posting: # 23213
Views: 4,871

Thank you Helmut. My latest question was due to my imprudence. My alternative of interst is the one with "AND", indeed.

But this exercise was still helpful since I naively expected the "OR" alternative to result in a smaller sample size compared with the "AND" alternative. I failed to realise that a type I error comes into play for the "OR" alternative, which explains a larger sample size (n=42 vs n=36).

Thank you also for modifying the R program. I sincerely appreciate your time and efforts.

And lastly, thank you for correcting me on the difference between wisdom and knowledge :-)

Thank you for sharing your knowledge!

Have a wonderful day!

Complete thread:

Sample size for 3-way crossover chrisk 2022-08-09 18:55 [Power / Sample Size]
- Sample size for 3-way crossover Helmut 2022-08-10 11:30
  - Sample size for 3-way crossover chrisk 2022-08-10 15:24
    - AND or OR, that’s the question Helmut 2022-08-10 15:58
      - AND or OR, that’s the questionchrisk 2022-08-10 17:46
        
        AND or OR, that’s the question Helmut 2022-08-10 20:59
        
        AND or OR, that’s the question chrisk 2022-08-10 22:00
        
        AND or OR, that’s the question Helmut 2022-08-11 15:25
        
        AND or OR, that’s the question chrisk 2022-08-12 16:02
        
        The unknown ρ Helmut 2022-08-17 15:04