Bioequivalence and Bioavailability Forum • Sample size for 3-way crossover

Sample size for 3-way crossover [Power / Sample Size]

posted by chrisk – 2022-08-10 17:24 (618 d 20:00 ago) – Posting: # 23211
Views: 4,902

Thanks again, Helmut, for sharing your wisdom so quickly and in details.

Since the alternative is based on T1 = R OR T2 = R, I am attempted to think that a larger sample size is required for the alternative T1 = R AND T2 = R. Is that indeed the case? If so, would you have any recommendation on how to approach the sample size estimation?

Thanks again, I very much appreciate your help!

Complete thread:

Sample size for 3-way crossover chrisk 2022-08-09 18:55 [Power / Sample Size]
- Sample size for 3-way crossover Helmut 2022-08-10 11:30
  - Sample size for 3-way crossoverchrisk 2022-08-10 15:24
    - AND or OR, that’s the question Helmut 2022-08-10 15:58
      - AND or OR, that’s the question chrisk 2022-08-10 17:46
        
        AND or OR, that’s the question Helmut 2022-08-10 20:59
        
        AND or OR, that’s the question chrisk 2022-08-10 22:00
        
        AND or OR, that’s the question Helmut 2022-08-11 15:25
        
        AND or OR, that’s the question chrisk 2022-08-12 16:02
        
        The unknown ρ Helmut 2022-08-17 15:04