Bioequivalence and Bioavailability Forum

Hi narra1813,

❝ Could you please explain if any compound is having inactive glucuronide metabolite and it's Cmax concentration was not available in the public domain. Which concentration need to spike to check the back conversion is happens to parent compound.

If you know the Cmax of parent and there is only a single metabolite, then you can do a worst-case scenario through realising that absent a lot of sorcery (and assuming this isn't endogenous) on a molar basis the metabolite should never reach a higher concentration than the parent when one parent molecule can result in one metabolite molecule. Look up the molar weights and convert mg/mL for parent and metabolite.
It may likely be a vast overkill in terms of realistic concentration, though, but if you do not have anything better to go by, this is the best I can come up with.