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RegisterCould we design the RCT as a non-inferiority trial at this situation? [Design Issues]
Dear all,
We plan to conduct a randomized controlled trial.
The goal of an RCT is to compare the difference of complication rates of CVD surgery between two groups (group A and group B).
The patients in group A will take medicine (traditionally treatment) and the patients in group B without taking medicine.
Notably, we want to design the RCT as a non-inferiority trial. That is, the effect of complication rates of patients without taking medicine in group B is not worse than the patients in group A with take medicine.
So, could we design the RCT as a non-inferiority trial?
Moreover, how to defining the non-inferiority margin at the situation?
Thanks a lot!
We plan to conduct a randomized controlled trial.
The goal of an RCT is to compare the difference of complication rates of CVD surgery between two groups (group A and group B).
The patients in group A will take medicine (traditionally treatment) and the patients in group B without taking medicine.
Notably, we want to design the RCT as a non-inferiority trial. That is, the effect of complication rates of patients without taking medicine in group B is not worse than the patients in group A with take medicine.
So, could we design the RCT as a non-inferiority trial?
Moreover, how to defining the non-inferiority margin at the situation?
Thanks a lot!
Complete thread:
- Could we design the RCT as a non-inferiority trial at this situation?dennis001 2022-07-24 17:39 [Design Issues]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Non-Superiority Helmut 2022-07-25 16:37
- Non-Superiority dennis001 2022-07-26 02:32
- Non-Superiority Helmut 2022-07-26 15:04
- Non-Superiority dennis001 2022-07-27 05:18
- Placebo effect Helmut 2022-07-27 12:17
- Non-Superiority dennis001 2022-07-27 05:18
- Non-Superiority Helmut 2022-07-26 15:04
- Non-Superiority dennis001 2022-07-26 02:32
- Could we design the RCT as a non-inferiority trial at this situation? ElMaestro 2022-07-26 12:44
- Could we design the RCT as a non-inferiority trial at this situation? dennis001 2022-07-27 05:21
- Non-Superiority Helmut 2022-07-25 16:37
Ing. Helmut Schütz