Bioequivalence and Bioavailability Forum • Potvin C consequences

Potvin C consequences [Two-Stage / GS Designs]

posted by mittyri – Russia, 2022-06-27 15:45 (1055 d 12:10 ago) – Posting: # 23093
Views: 4,325

Hi ElMaestro,

some more questions

❝ Your type I error is not depending on your estimates and thus not depending on whether you went into stage 2 or not.

OK, what about this:

power.tsd(method = "C", CV = 0.2, n1 = 12, theta0 = 1.25)



p(BE)    = 0.0511



power.tsd(method = "C", CV = 0.3, n1 = 12, theta0 = 1.25)



p(BE)    = 0.043743

So T1E (OK, maximum type I error) depends on the CV, isn't it?
Or may be I misunderstood your point and we should not verify T1E during estimation process since we are assuming that the framework was stated as acceptable in the Protocol?

—
Kind regards,
Mittyri

Complete thread:

T1E after 1st stage in Power2Stage mittyri 2022-06-24 13:43 [Two-Stage / GS Designs]
- T1E after 1st stage in TSDs Helmut 2022-06-24 14:33
  - T1E after 1st stage in TSDs mittyri 2022-06-24 21:12
    - T1E after 1st stage in TSDs Helmut 2022-06-25 14:07
      - Potvin C consequences mittyri 2022-06-25 23:29
        
        Potvin C consequences ElMaestro 2022-06-26 09:11
        
        Potvin C consequencesmittyri 2022-06-27 13:45
        
        Potvin C consequences Helmut 2022-06-27 14:49
        
        from Potvin C to Inverse Normal mittyri 2022-06-27 17:13
        
        From Potvin C to Inverse Normal: history (and outlook?) Helmut 2022-06-27 18:54
        
        Potvin C consequences ElMaestro 2022-06-27 17:13
        
        true CV ≠ observed CV mittyri 2022-06-27 17:22
- T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 18:25
  - T1E after 1st stage in Power2Stage mittyri 2022-06-24 21:05
    - T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 22:55