Potvin C consequences [Two-Stage / GS Designs]

posted by mittyri – Russia, 2022-06-26 01:29 (756 d 11:52 ago) – Posting: # 23087
Views: 2,560

Hi Helmut (and ElMaestro - sorry to post in this thread, but all your answers are great!),

❝ Of course, ElMaestro is right.

There Can Be Only One.

OK, I understand the logic here.
take a look at some (theoretical) situation: a Sponsor goes with Potvin C (don't ask me why), moreover, he proved that with the current CV and n1 T1E does not exceed 5%.
But as you showed in the lectures and in example above, Potvin C could not ensure 5% for all combinations. Thus, during stage 1 the CV was lower and the resulted T1E was out of 5%.
What would be the right (safe) way out in such situation?

Kind regards,

Complete thread:

UA Flag
 Admin contact
23,112 posts in 4,858 threads, 1,644 registered users;
68 visitors (0 registered, 68 guests [including 19 identified bots]).
Forum time: 13:22 CEST (Europe/Vienna)

It’s always fun to have your models validated,
but is way more fun to have them trashed.
Finding out you are completely wrong
is a great part of science.    G. Randall Gladstone

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz