T1E after 1st stage in Power2Stage [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2022-06-24 20:25 (217 d 03:19 ago) – Posting: # 23082
Views: 1,107

Hi Mittyri,

❝ could you please guide me regarding the function to be used for T1E estimation after 1st stage of Potvin methods (Power2Stage R package)?


That would be a misnomer, I think. The T1E is a property of the testing approach. There is an alpha at stage 1 and there is an alpha at stage 2 but there is no T1E at stage 1 (or 2). There is just a well-defined T1E for the approach.
Mixing up the terms alpha and T1E is a real danger for 2-stage approaches, since in "normal" trials they are one and the same.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
22,477 posts in 4,708 threads, 1,603 registered users;
17 visitors (0 registered, 17 guests [including 7 identified bots]).
Forum time: 22:44 CET (Europe/Vienna)

In these matters the only certainty is
that nothing is certain.    Pliny the Elder

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5