T1E after 1st stage in Power2Stage [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2022-06-24 20:25 (162 d 10:59 ago) – Posting: # 23082
Views: 1,013

Hi Mittyri,

❝ could you please guide me regarding the function to be used for T1E estimation after 1st stage of Potvin methods (Power2Stage R package)?


That would be a misnomer, I think. The T1E is a property of the testing approach. There is an alpha at stage 1 and there is an alpha at stage 2 but there is no T1E at stage 1 (or 2). There is just a well-defined T1E for the approach.
Mixing up the terms alpha and T1E is a real danger for 2-stage approaches, since in "normal" trials they are one and the same.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
22,427 posts in 4,694 threads, 1,598 registered users;
15 visitors (0 registered, 15 guests [including 8 identified bots]).
Forum time: 06:24 CET (Europe/Vienna)

Operational hectic replaces
intellectual calms.    Alexander Huiskes

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5