Center term in Bioequivalence Study [Study As­sess­ment]

posted by ElMaestro  – Denmark, 2022-06-08 13:14 (23 d 11:37 ago) – Posting: # 23048
Views: 244

Hi balakotu,

in the circumstance, however regrettable the situation is, you have to deal with it.
Perhaps I would lump centers with less than x subjects into one supercenter with a certain lump size. This is a common thing to do in certain equivalence studies and it has acceptance in both US and EU (but mind you, these things should ideally, as Helmut gently hints at, be pre-specified).

Go for x=6 or 8 or something. But you're in for a barrage of questions whatever you do.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
22,181 posts in 4,647 threads, 1,572 registered users;
online 7 (0 registered, 7 guests [including 7 identified bots]).
Forum time: Saturday 00:52 CEST (Europe/Vienna)

Reach for the stars,
even if you have to stand on a cactus.    Susan Longacre

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5