Bioequivalence and Bioavailability Forum

Dear Laura,

❝ The participants will be added to the groups accordingly with the administration date of the first period (even if the other periods can have a different administration date) or the groups shall be formed accordingly with the date of administration of all the periods (for each group all the administration date of the 4 periods has to be the same)?

I would use the groups with equal administration dates, so the periods are equal within the groups. It won't hurt (CIs won't significantly change) and does not raise the questions since you are following some internal logical rules (different period dates -> different groups).