Bioequivalence and Bioavailability Forum • Back Calculating Sample Size

Back Calculating Sample Size [Power / Sample Size]

posted by dshah – India, 2022-05-13 13:54 (983 d 21:22 ago) – Posting: # 22985
Views: 3,749

Hi All!

Even I am getting around CV = 156% (pooled variance estimate) considering N=140 (N=70/group).
Only when N=70 is considered, I am getting CV~92%.

Dear Sereng! From the details of Cmax (Ref): 478 +/- 434 (mean +/- SD) and Cmax (Test): 489 +/- 909 (mean +/- SD), it can be seen that reference Cmax is less variable than test one which is opposite to what is stated in original post. Or is it typo?

Regards,
Divyen

Complete thread:

Back Calculating Sample Size Sereng 2022-05-12 17:40 [Power / Sample Size]
- Back Calculating Sample Size ElMaestro 2022-05-12 22:29
  - Back Calculating Sample Size Helmut 2022-05-12 23:10
    - Back Calculating Sample Size ElMaestro 2022-05-13 01:38
    - Back Calculating Sample Size Sereng 2022-05-18 05:32
      - PowerTOST: Total sample size Helmut 2022-05-18 08:55
  - Back Calculating Sample Sizedshah 2022-05-13 11:54
    - Algebra Helmut 2022-05-16 15:01
      - Algebra d_labes 2022-05-16 18:58
- Parallel designs: Don’t use the (conventional) t-test! Helmut 2022-05-17 14:17