Bioequivalence and Bioavailability Forum • Range

Range [BE/BA News]

posted by Ohlbe – France, 2022-04-11 17:48 (890 d 01:09 ago) – Posting: # 22926
Views: 6,469

Hi Helmut,

❝ ❝ Range: no expectation described. No idea.

❝

❝ The range is completely useless. Like the mean it has a breakdown point of zero. Imagine with $\small{n\rightarrow \infty}$: $$\small{\left\{R_1=1,\ldots, R_n=1\phantom{.25}\right\} \rightarrow \textrm{Range}(R)=0\phantom{.25}}\\\small{\left\{T_1=1,\ldots, T_n=1.25\right\} \rightarrow \textrm{Range}(T)=0.25}$$ Good luck in calculating a ratio.

I guess it depends what they mean by "range". Are they using the word in its statistical meaning (difference between the largest and smallest values) or in its lay language meaning (limits between which something varies) ? I suspect the latter: lowest and highest observed T_max values.

—
Regards
Ohlbe

Complete thread:

EMA: New product-specific guidances Helmut 2022-04-08 15:17 [BE/BA News]
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        RangeOhlbe 2022-04-11 15:48
        
        Range Helmut 2022-04-11 16:07
        
        Range Ohlbe 2022-04-11 16:20
        
        Range Helmut 2022-07-28 14:43
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        Preliminary simulations Helmut 2022-05-01 15:56
        Revisions of the PSGLs final Helmut 2023-06-23 13:29
        
        Revisions of the PSGLs final dshah 2023-06-28 14:43
        
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      - Simulated distributions Helmut 2022-05-02 13:43