Bioequivalence and Bioavailability Forum • “Spaghetti plots”

“Spaghetti plots” [Software]

posted by Helmut – Vienna, Austria, 2022-04-07 17:23 (1022 d 18:50 ago) – Posting: # 22915
Views: 4,480

Hi Shatha,

❝ ❝ Where does the graph come from?

❝ I don't know, I received it by email as a separate graph. I tried to find the reference but I didn't get it.

Maybe ask the one who sent it to you for the source.

❝ spaghetti plots and plots of geometric means are the XY plots that are usually generated in WinNonlin, right? As I'm not familiar with the term "spaghetti plots".

“Spaghetti plots” (i.e., overlays of subjects’ time course of concentrations grouped by treatment) is parlance used by the PK community. You plot the lines and omit the data points. Few references.^1,2

Bonate PL. Pharmacokinetic-Pharmacodynamic Modeling and Simulation. New York: Springer; 2^nd ed. 2011. p. 359.
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications. Stockholm: Apotekarsocieteten; 5^th ed. 2016. p. 335–6, p. 704.

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Complete thread:

SAS: Helmert transformation Shatha 2022-04-04 13:35 [Software]
- Helmert transformation? Helmut 2022-04-04 14:23
  - Helmert transformation? Shatha 2022-04-05 12:00
    - Steady-state achievement Helmut 2022-04-05 14:29
      - Steady-state achievement Shatha 2022-04-06 11:38
        
        Steady-state achievement Helmut 2022-04-06 14:29
        
        Steady-state achievement Shatha 2022-04-07 10:58
        
        “Spaghetti plots”Helmut 2022-04-07 15:23