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RegisterHelmert transformation? [Software]
posted by Helmut 
– Vienna, Austria, 2022-04-04 16:23 (745 d 20:38 ago) – Posting: # 22907
Views: 2,723
Hi Shatha,
You can’t verify anything in science.
In statistics you can only try reject a properly stated null hypothesis – which is in your case what? Any test at level \(\small{\alpha}\) has an unavoidable false positive rate. Do you want to exclude \(\small{(100\times\alpha)\%}\) of subjects although they are in (pseudo) steady state?
Do you have a reference demonstrating its application in PK? Never came across this approach in 40+ years. See there why statistical tests are nonsense – essentially because we don’t have a proper null.
❝ I have 2 treatments, 2 periods, crossover, multiple dose, steady state study.
❝ The last 3 pre-dose concentrations should be used for steady state verification for each subject in each period.
You can’t verify anything in science.
In statistics you can only try reject a properly stated null hypothesis – which is in your case what? Any test at level \(\small{\alpha}\) has an unavoidable false positive rate. Do you want to exclude \(\small{(100\times\alpha)\%}\) of subjects although they are in (pseudo) steady state?
❝ I need your help to perform this verification using Helmert transformation method …
Do you have a reference demonstrating its application in PK? Never came across this approach in 40+ years. See there why statistical tests are nonsense – essentially because we don’t have a proper null.
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- SAS: Helmert transformation Shatha 2022-04-04 13:35
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Helmert transformation?Helmut 2022-04-04 14:23
- Helmert transformation? Shatha 2022-04-05 12:00
- Steady-state achievement Helmut 2022-04-05 14:29
- Steady-state achievement Shatha 2022-04-06 11:38
- Steady-state achievement Helmut 2022-04-06 14:29
- Steady-state achievement Shatha 2022-04-07 10:58
- “Spaghetti plots” Helmut 2022-04-07 15:23
- Steady-state achievement Shatha 2022-04-07 10:58
- Steady-state achievement Helmut 2022-04-06 14:29
- Steady-state achievement Shatha 2022-04-06 11:38
- Steady-state achievement Helmut 2022-04-05 14:29
- Helmert transformation? Shatha 2022-04-05 12:00
- Helmert transformation?Helmut 2022-04-04 14:23
Ing. Helmut Schütz