Bioequivalence and Bioavailability Forum

Helmert transformation? [Software]

posted by Helmut – Vienna, Austria, 2022-04-04 16:23 (1154 d 01:29 ago) – Posting: # 22907
Views: 5,207

Hi Shatha,

❝ I have 2 treatments, 2 periods, crossover, multiple dose, steady state study.

❝ The last 3 pre-dose concentrations should be used for steady state verification for each subject in each period.

You can’t verify anything in science.
In statistics you can only try reject a properly stated null hypothesis – which is in your case what? Any test at level \(\small{\alpha}\) has an unavoidable false positive rate. Do you want to exclude \(\small{(100\times\alpha)\%}\) of subjects although they are in (pseudo) steady state?

❝ I need your help to perform this verification using Helmert transformation method …

Do you have a reference demonstrating its application in PK? Never came across this approach in 40+ years. See there why statistical tests are nonsense – essentially because we don’t have a proper null.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

SAS: Helmert transformation Shatha 2022-04-04 13:35 [Software]
- Helmert transformation?Helmut 2022-04-04 14:23
  - Helmert transformation? Shatha 2022-04-05 12:00
    - Steady-state achievement Helmut 2022-04-05 14:29
      - Steady-state achievement Shatha 2022-04-06 11:38
        
        Steady-state achievement Helmut 2022-04-06 14:29
        
        Steady-state achievement Shatha 2022-04-07 10:58
        
        “Spaghetti plots” Helmut 2022-04-07 15:23

Hel­mert trans­for­ma­tion? [Software]

Complete thread:

Helmert transformation? [Software]