Hel­mert trans­for­ma­tion? [Software]

posted by Helmut Homepage – Vienna, Austria, 2022-04-04 16:23 (239 d 17:32 ago) – Posting: # 22907
Views: 1,136

Hi Shatha,

❝ I have 2 treatments, 2 periods, crossover, multiple dose, steady state study.

❝ The last 3 pre-dose concentrations should be used for steady state verification for each subject in each period.

You can’t verify anything in science.
In statistics you can only try reject a properly stated null hypothesis – which is in your case what? Any test at level \(\small{\alpha}\) has an unavoidable false positive rate. Do you want to exclude \(\small{(100\times\alpha)\%}\) of subjects although they are in (pseu­do) steady state?

❝ I need your help to perform this verification using Helmert transformation method …

Do you have a reference demonstrating its application in PK? Never came across this approach in 40+ years. See there why statistical tests are nonsense – essentially because we don’t have a proper null.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
 Admin contact
22,418 posts in 4,693 threads, 1,598 registered users;
18 visitors (0 registered, 18 guests [including 11 identified bots]).
Forum time: 08:56 CET (Europe/Vienna)

Intellect distinguishes between the possible and the impossible;
reason distinguishes between the sensible and the senseless.
Even the possible can be senseless.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz