Bioequivalence and Bioavailability Forum • R2adj improvement limit

R2adj improvement limit [Regulatives / Guidelines]

posted by mittyri – Russia, 2022-03-22 12:31 (1027 d 12:06 ago) – Posting: # 22858
Views: 5,281

Hi Helmut,

❝ The default automatic algorithm in Phoenix WinNonlin (and most other software I know) is starting with the last three concentrations and maximizing \(\small{R_\textrm{adj}^2}\) until the improvement by adding data is ≤0.0001.

I was always wondering: why the limit is ≤0.0001? Not simple <0? Or maybe ≤0.01?

—
Kind regards,
Mittyri

Complete thread:

Kel Calculation in ANVISA Regulatory MGR 2022-03-21 07:30 [Regulatives / Guidelines]
- Data, please Helmut 2022-03-21 11:12
- ANVISA’s strange examples Helmut 2022-03-21 18:38
  - R2adj improvement limitmittyri 2022-03-22 11:31
    - R2adj improvement limit Helmut 2022-03-22 14:04