## R2adj improvement limit [Regulatives / Guidelines]

Hi Helmut,

» The default automatic algorithm in Phoe­nix WinNonlin (and most other software I know) is starting with the last three concentrations and maximizing $$\small{R_\textrm{adj}^2}$$ until the improvement by adding data is ≤0.0001.

I was always wondering: why the limit is ≤0.0001? Not simple <0? Or maybe ≤0.01?

Kind regards,
Mittyri