## Typos… [Regulatives / Guidelines]

» Well, the formula given in Health Canada’s old guidance(s) is correct. In the example instead of $$\small{0.0360}$$ plug in $$\small{\log_{e}\tfrac{Potency_\textrm{ R}}{Potency_{\,\textrm{ T}}}}$$.
» Alternatively, multiply all dose-related PK metrics (Cmax, AUC) of $$\small{\textrm{T}}$$ with $$\small{Potency_\textrm{ R}}$$ and the ones of $$\small{\textrm{R}}$$ with $$\small{Potency_\textrm{ T}}$$. Perform the comparison with the corrected values and you should obtain the same result than with the correction formula.

Thank you. I performed this step for a balanced design and the results were similar.

It is also applicable for unbalanced design, right?