Apixaban PK pecularities [PK / PD]

posted by BE-proff – 2022-03-14 21:17 (708 d 06:06 ago) – Posting: # 22836
Views: 1,471

Hi All,

According to Apixaban PIL its kinetics has some peculiarities::lookaround:

1) AUC is 32% higher in patients aged over 65
2) AUC is 18% higher in women
3) AUC is 30% higher in patients with body weight below 50 kilos.

Will it be correct to say (using extrapolation) that if a slim woman aged 70 takes 2.5 mg of apixaban the "actual dose" is close to 5.0 mg? :confused:

From the point of safety the question is important :wink:

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